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KMID : 0363020080380020179
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Journal of Korean Academy of Periodontology
2008 Volume.38 No. 2 p.179 ~ p.189
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The effect of micro-macroporous biphasic calcium phosphate incorporated with polyphosphate on exophytic bone regeneration
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Kim Dong-Hwan
Herr Yeek
Kwon Young-Hyuk
Park Joon-Bong
Chung Jong-Hyuk
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Abstract
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Purpose: In this study, the effect of micro-macroporous biphasic calcium phosphate(MBCP) incorporated with inorganic polyphosphate for bone regeneration in the calvaria of rabbit was evaluated.
Materials and Methods: The procedure of guided bone regeneration was performed with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. Four animal groups were compared : 1) TR-ePTFE membrane for negative control group, 2) TR-ePTFE membrane filled with MBCP for positive control group, 3) TR-ePTFE membrane filled with MBCP soaked in 4% inorganic polyphosphate for experimental group I, and 4) TR-ePTFE membrane filled with MBCP soaked in 8% inorganic polyphosphate for experimental group II.
Results: 1. Negative control group showed the highest new bone formation at 16 weeks. 2. Positive control group showed the smallest new bone formation compared to other groups. 3. 8% inorganic polyphosphate induced more volume of bone formation, otherwise experimental group II did not show significant difference compared to negative control group.
Conclusion: These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration, possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue.
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KEYWORD
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MBCP, polyphosphate, exophytic bone regeneration
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